Bioactive natural compounds can correct breast cancer and even TNBC

Bioactive natural compounds can correct breast cancer and even TNBC


Triple Negative Breast Cancer (TNBC) is usually thought to be bad news within orthodox medicine because the oncologists just do not have any drugs to treat it. Women who develop it often feel doomed. Fortunately, the Science of Epigenetics may be coming to the rescue, having already identified bioactive natural compounds as real treatment options both for TNBC; and breast cancer in general.

This article starts with TNBC and some of the bioactive natural compounds known to be capable of having an effect. Then goes on to look at breast cancer as a whole.

Breast cancer, TNBC and bioactive natural compounds

Up to 15 per cent of breast cancers are TNBC and, worryingly, it tends to be found in younger women and it tends to be more aggressive.

But over the last decade, more and more research has been recorded showing how bioactive natural compounds have an effect in preventing and correcting breast cancer, and even with TNBC. Below, we start with TNBC and natural compounds but then move on to some of the research on Triple Negative Breast Cancer and bioactive compounds.

It is quite clear that certain foods hold the ability to ‘Protect and Correct’ against cancer.


We have a book The Rainbow Diet’, which goes into both Epigenetics and Protect and Correct in a simple way, even including shopping lists!

Since 2006 there has been an ‘explosion’ in research into complementary therapies with ‘overwhelming’ evidence that factors such as diet can ‘increase survival and even prevent a cancer returning’, according to the American Cancer Society, not just CANCERactive.

The Science of Epigenetics and breast cancer

Epigenetics is a science that has boomed since 1995. It holds that an individual is controlled by factors other than its core DNA sequence. Epigenetic changes (’epi’ meaning surrounding) can switch genes on and off, ’silencing genes’ and blocking their messages.  

The idea of a mutation in the core structure of your DNA is so rare as to be a medical myth. Doctors talking of mutations in your DNA are actually being lazy. They imply that there has been a change to the core DNA structure, when actually the vast majority of changes occur around the DNA in the skeletal structure.

What really happens is that your DNA, which is about 1.8 metres long, is held in a tight ball in your cell nucleus by histones. These histones hold it by chemical bonds effected by methylation or acetylation. 

Prior to chronic illnesses like Alzheimer’s or cancer, people experience increased levels of homocysteine in the blood stream. This causes more methylation and more histones. And when these extra histones sit on the DNA, they can block messages from the underlying, perfect, DNA. Now you are in trouble. Lost messages which would have told your immune system to attack a rogue cell, or would have controlled cell division, can be extremely dangerous. 


Addenbrooks, Cambridge, researchers have shown that apart from being predictive of diseases such as cancer and dementia, high levels of homocysteine link to heart disease, while higher levels of plasma B vitamins like folic acid/folate lower homocysteine levels and are preventative. 

The Science of Epigenetics has shown that these changes occur in response to 4 factors  - diet, environmental toxins, stress and hormones – each and all can affect the EXPRESSION of the core genes by changing the methylation bonding. The science has also shown that these changes can even be passed on to future generations.

Homocysteine and folate

Just as the methylation can be increased by homocysteine, so it can be corrected in the other direction. And the new chemical bonds formed by environmental toxins and poor diet can also be corrected. It is quite understandable in the world of biochemistry that chemical reactions like methylation and acetylation can be reversed.  Folic acid or folate has long been known to be protective in cell division. Now, increasingly, many bioactive compounds in nature are being shown to have positive effects.


Yes, you can reverse the process. Yes, you can unblock restricted gene expression. No, you are not doomed.

Go to: Epigenetics and reversing cancer

and, 

Go To: The best epigenetic natural compounds


Orthodox medicine and TNBC

TNBC is a problem for oncologists. It doesn’t fit any of their formulae for best practice. It isn’t oestrogen-driven, so that rules out Tamoxifen and Aromatase Inhibitors. It isn’t progesterone or HER-2 driven either.

Often oncologists resort to common, old fashioned chemo drugs that just kill rapidly dividing cells (all of them, including your hair and finger nails) or something newer like Taxol/Paclitaxel, where there was German research presented at the European breast cancer symposium showing six months after treatment the drug encourages metastases!

In America now, patients are told by their oncologist that it has a positive effect in less than three per cent of women.

Reversing methylation in breast cancer

‘It is now known that abnormal histone modification in combination with DNA hypermethylation is frequently associated with epigenetic silencing of tumour suppressor genes and genomic instability in breast cancer’, so says a report by scientists looking to develop drugs that can reverse the process.

But it is not just the changed bonds around the DNA that pose a target, it is the enzymatic processes that cause acetylation and methylation in the first place, as well. Histone lysine methylation is known to be a reversible process’ and researchers are looking for ‘drugs that can act as Histone Methyltransferase and Demethylase Inhibitors in Breast Cancer’.

The good news is that the Science of Epigenetics has already shown that there are bioactive natural compounds capable of affecting the methylation and structural faults.

Triple Negative Breast Cancer and bioactive Natural Compounds

So what might a woman with TNBC look to help her take some control?Here are just a few of the papers we have covered in Cancer Watch:

  1. Vitamin D -  Go To: Two studies show vitamin D can correct TNBC

  2. Indole 3 Carbinol/DIM – Go To: Indole 3 carbinol and Dim can fight breast cancer - TNBC or ER+

  3. Curcumin – can form a number of gene controlling functions with TNBC and breast cancer. For example 

      (i)  Curcumin wakes up tumour suppressor genes

      (ii) Curcumin inhibits metastases

  4. Green TeaGreen tea slows TNBC development

  5. BlueberriesBlueberry powder shown to reduce TNBC tumour size and metastases

  6. Rose Hips - Rose hips have effect in TNBC

  7. Luteolin - Luteolin can reduce metastases in TNBC and inhibits VEGF

And more generally, for breast cancer:

   8.  FolateFolate supplementation prevents breast cancer

   9. Carotenoids Carotenoids can prevent breast cancer and also prevent it returningCarotenoids are a strong element in The Rainbow Diet.

   10. Conjugated Linoleic Acid - CLA has epigenetic benefits against breast cancer even at low levels

   11. Breast Defend
A 2012 research study at Indiana University Health showed that a branded compound called BreastDefend reduced metastases and progression in TNBC.

The ingredients were

* Modified Citrus Pectin
* Indole 3 Carbinol/DIM
* Extracts from Medicinal mushrooms (Coriolus versicolor, Ganoderma lucidum, Phellinus linteus)
* Medicinal herbs (Scutellaria barbata, Astragalus membranaceus, Curcuma longa)

After a round of in vitro testing, the product was used with mice where it reduced lung progression from 67% to just 20% (Click here)  

   12. Melatonin - Melatonin works 5 ways against breast cancer

   13. Resveratrol - Resveratrol stops malignant spread of breast cancer

   14. Red Grape Polyphenols - red grape phenols inhibit breast cancer progression

   15. Mushrooms - mushrooms can inhibit aromatase enzymes

   16. Ginger - Ginger may be better than drugs at fighting breast cancer

   17. Environmental toxins - Environmental toxins can poison for generations


"If you are already thinking about buying any of these compounds you might look at what Our Natural Selection has on offer in its online shop - click here to go to the shop".

Epigenetics and reversing cancer
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