Adcetris or brentuximab vedotin

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New ’biologic’ drug made by Seatle Genetics. This targets lymphoma and costs roughly 9,000 pounds or $16,000 US a month. The mean increased survival time in research was 7 months. 



The FDA has approved brentuximab vedotin, brand name Adcetris, for the treatment of HL (Hodgkin lymphoma) and ALCL (systemic anaplastic large cell lymphoma). Adcetris consists of a drug and an antibody - an antibody-drug conjugate - the antibody directs the drug to CD30, a target on lymphoma cells.



Adectris was approved under the FDA’s accelerated approval programme. However

the FDA approved Adcetris after evaluating a single-arm clinical trial with only 102 participants. Patients received only Adcetris. The human study’s endpoint was objective response rate - what percentage of participants’ tumours either shrank or disappeared altogether after treatment. 73% of them achieved either a partial or complete response, and responded to therapy for 6.7 months (average).



The systemic ALCL single-arm clinical trial involved only 58 patients. They received only Adcetris. The primary endpoint was the same; Objective response rate. 86% of them achieved either a partial or complete response, and responded for 12.6 months (average).



Side effects seem the usual nausea, fatigue, white cell decline, upper respiratory infection and sickness.
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