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Gc-MAF a natural Immunotherapy

Gc-MAF or GcMAF? Either way, is it a cure for cancer?

Gc-MAF or GcMAF is a natural protein-derived macrophage activating factor derived from a functional change in the Gc protein, which is a vitamin D binding protein. 

In simple English, Gc-MAF (which is a naturally occurring protein in the body) kicks macrophages (a type of white cell which kills invasive cells) into action so that they can then attack and destroy cancer cells (and indeed almost all rogue cells - like viruses).

In people with cancer (and viral illnesses), production of Gc-MAF is blocked by an enzyme called Nagalase, which is produced by many cancers and viruses in order to beat the immune system. 

The idea is simple - inject patients with Gc-MAF and overcome the blockage, and so macrophages can be stimulated to do their job.

Gc-Maf - a Natural Immunotherapy?

Immunotherapy is all the buzz at the moment. Full of promise (but we’ve heard that before), in fact, the results are a bit mixed. One possibility is that immunotherapy needs to be specifically tailored to the individual patient (for example, as with Dendritic cell therapy).

There are many different cells in the immune system and they all do different jobs. Some of them need help. You can boost their numbers (with drugs or herbs), but then they need to ´see´ the opposition - polysaccharides help here. They also cannot attack a cancer cell until a T-lymphocyte ‘picks up’ a vitamin D molecule. And research says taking probiotics is essential to make them work better!

Gc-MAF is claimed to be very potent and even at low concentrations seems to activate, regulate and expand macrophages. The manufacturers (Immuno Biotech) say that it costs only a fraction of the price of a chemotherapy drug.

(A Macrophage Activating Factor is a lymphokine that primes macrophages to kill tumour cells). I really am trying to keep this simple, honestly.

Research on Gc-Maf?

In one study (Anticancer Res. 2013 Jul;33(7):2917-9, Inui T, Kuchiike D, Kubo K, Mette M, Uto Y, Hori H, Sakamoto N.) The researchers set about tailoring an immune response with  an integrative immunotherapy approach using second-generation group-specific component macrophage activating factor (GcMAF)-containing human serum. Other studies have involved breast cancer, colon and prostate cancer - and even HIV. Some studies were by a Dr Yamamoto. However, after analysis of the studies by the Anticancer Fund, even though editors had previously accepted articles as valid, Yamamoto has withdrawn a paper on breast cancer. Articles have criticised research standards in the ´clinical trials´. See below.

How did they build this ´Integrative immunotherapy´ approach?

The standard protocol used by these researchers was:

A GcMAF-containing human serum administered intramuscularly or subcutaneously once or twice per week for the duration of cancer therapy until all cancer cells are eradicated.

This was studied with hyper T/natural killer (NK) cell therapy, which was given once per week for six weeks; and

High-dose vitamin C administered intravenously twice per week; and, 

Alpha lipoic acid (600 mg) administered orally daily; and,

And vitamin D3 (5,000-10,000 IU) administered orally daily.

Did Gc-Maf work?

By March 2013, Saisei Mirai had treated over 345 patients with GcMAF. In the cases of three patients, the integrative immunotherapy was ‘remarkably effective’. Given the results seem hopeful, a comparative clinical study is planned.

The Gc-Maf overclaim?

3 out of 345 sounds pretty low to me.

However, the treatment was originally developed by an American, Dr Nobuto Yamamoto who was claiming it worked 100% of the time on breast, prostate, colorectal and other cancers. This followed three clinical trials he conducted. Critics claim the numbers were small with approximately 20 patients in each (but I’ve seen brain cancer drugs in a blaze of glory following research with 16 people, so the jury – my jury – is out on that one). Far more importantly. He didn’t use control groups. They might have all survived the research period too.

Availability of Gc-Maf

There is actually a website called On it, it states  ‘As of February 2013, on the American National Library of Medicine alone, 142 eminent scientists from 8 nations have published 59 major GcMAF research papers. These can be viewed on the US Government’s Pubmed system.

Our GcMAF is the only publicly available GcMAF that is used in these research papers’.

So it isn´t just an immunotherapy - it´s a brand too. And Lord Saatchi is used to pop up on the front of the website trying to get you to sign the petition for his House of Lords bill to free up oncologists to try these treatments. It looks like he is endorsing GcMAF. Perhaps he totally believes in it and is?

The research studies are listed and referenced in full. And there are lots of them.

What do we think at CANCERactive?

We have actually done a lot of research on immunotherapy. It´s not new - oncologists have been using Interferon and Interleukin for years - but many don´t seem to fully appreciate the need for vitamin D and alpha lipoic acid to help it all work.

Then there´s Dendritic Cell Therapy and others. We´ve also covered new immunotherapy drugs for melanoma, prostate and bladder cancer. We have a full review of immunotherapy which is updated regularly.

Go To: A review of Cancer Active Immunotherapy

The aim of the game is to boost your immune system to recognize and then attack the rogue cancer cells. Many immunotherapies use samples of the cancer and your body´s white cells to tailor make the perfect attackers. And so immunotherapy is usually about getting your own immune system to work harder.

The sad part is that if you could preserve your immune system rather than seriously damaging it with drugs, there are many ways you can boost it yourself. In 2016, research in Cancer Watch showed that people who ate high levels of soluble fibre had the strongest immune systems. It´s all about your gut bacteria. 

On the GcMAF website, the ´treatment´ protocol talks about diet and avoiding sugar - it seems a standard ketogenic diet. It talks of increasing oxygen levels and the importance of exercise. And of the need for trace minerals and amino acids. Oh, and vitamin D. Have they been reading my book, ´Everything you need to know to help you beat cancer?´

Click here to find out more about the book ´Everything you need to know to help you beat cancer.

But there´s also some slightly questionable stuff in the Gc-Maf protocol - you need to take molybdenum, and have your root canals removed. ´Eye of newt, tongue of toad´ - sorry that´s just me, playing.

´If you are already thinking of buying Vitamin D, you might like to look at the Natural Selection shop by clicking here´.

So, we could have something that helps here if it genuinely does reboot your immune system, or it could be that the rest of the Integrative package is the mainstay treatment. After all the American Cancer Society says you can increase survival and even prevent a cancer returning by diet and exercise. And it seems a Rainbow diet (or even a Ketogenic diet) is a good place to start.

As always, so Phase III clinical Trials would be helpful. But they are going to have to be done with two control groups. The trial group can do the ´protocol´ in full; the first control group can use a placebo, but still do the vitamin D plus diet and exercise; while the second control group can carry on being tubs of lard in front of the TV. 

That should sort it.

Immunotherapy is full of potential. And having people that understand the need for vitamin D, alpha lipoic acid, polysaccharides, no glucose, IVC, increasing oxygen levels etc. is very good news for cancer patients. Oncologists treating patients with Interferon or Interleukin, please note.

If it works, which bit did the trick? Would you care? Of course you could start with the diet and exercise and vitamin D, and a few other things we tell you about constantly, and see how you get on, before shelling out 600 - 700 euros for a course of GcMAF.

You can go the whole hog with a trip to the clinic in Switzerland, and you should note that you need to keep taking GcMAF for 8 weeks after the tumours have gone.

There´s confidence for you.

Apparently it also works with ME and Autism. And you should keep taking your supplements, especially the ones that boost your immune system. The odd dribble of Royal Jelly seems to help. 

Conspiracy Theories

The conspiracy theorists are at work in America right now about this, saying that Nagalase is being included in vaccines (even child vaccines) because otherwise natural Gc-MAF in the body would just wipe out the viral part of the vaccine. And some holistic doctors (like Dr. Jeff Bradstreet and team) believed that Nagalase is directly linked to Autism and other illnesses. There were claims that Bradstreet´s team actually found nagalase in vaccines and had to code conversations between them. Whatever. The Clinic was raided and everything removed. Three days later Dr. Bradstreet committed suicide. It was rather puzzling that he would choose to do this by shooting himself as he drove into a river, especially since as a doctor he would have had access to gentler ways of dying.

UK importation of Gc-Maf has (Feb 2015) been banned from Guernsey (there was a clinic there), Cancer Research UK (as usual) says it´s risky stuff (or words to that effect) and last July even Nat West in Guernsey stopped the company´s bank account. The UK ´factory´ in Milton, Cambridgeshire was suddenly ´inspected´ after a complaint from Guernsey that the blood plasma starting material was not for use in humans or drugs. However, having seized 10,000 vials of the product and warned various countries who were using this ´unlicensed medicine´, the MHRA did say that they had received no reports of problems or side-effects. These particular products were all labelled ´First Immune´ and the MHRA say they are ´not licensed medicines, and have not been tested for quality, safety or effectiveness´.

Despite this, some 6 months later a BBC investigative journalist still found it for sale in Guernsey - a vial can set you back 700 euros and a month´s treatment can cost $1,000. 

Swiss authorities have investigated the company. There are apparently 10 ´factories´ worldwide. We had a cancer patient in Japan who was recommended to use the product by his oncologist. The product is banned by the FDA in America.

There´s some strong feelings out there. Of course conspiracy theorists smell the hand of Big Pharma here especially given that GC-Maf is cheap, non-invasive and, anecdotally, it does seem to work a bit.

We note that Dr Meheus of the Anticancer fund justified their attacks on Gc-MAF by saying "Our goal is to avoid that cancer patients are misled by seemingly scientific evidence that turns out to be of questionable quality". If he really believes that, he is going to have his work cut out. Fraud, lies, falsified research and more were exactly the charges laid at the door of Pharmaceutical Companies by Peter Goetzsche Head of the prestigious Nordic Cochrane Centre in his book "Deadly Medicines and Organised Crime. How Big Pharma has Corrupted Healthcare".

It´s the usual mess that surrounds most non-toxic, non-invasive treatments that are a potential threat to Big Pharma - and as usual, it is the patient who suffers. We don´t really have a clue whether this works or not! Maybe that´s the idea. But, in truth to beat the expensive new immunotherapy drugs it only needs a long-term effect in 8% of patients. 7% is the norm for most so far.

It would help if they did quality research and clinical trials that were above reproach though.

Read more on the Immuno Biotech site. And HERE on the website of Alternative Health.

People who read this also read

Vitamin D - are you getting enough?

The ketogenic Diet

The Rainbow Diet

Intravenous Vitamin C


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