Melatonin makes Tamoxifen work better

Melatonin makes Tamoxifen work better

Melatonin helps Tamoxifen work

Researchers from the Tabriz University of Medical Sciences in Iran have shown that wrapping the sleep hormone melatonin in lipid particles, increases delivery into the body and can help Tamoxifen work much more effectively.

Indeed, the main benefit seems to be that far less drug can be used to do the same job, meaning you can use less and have much lower side-effects. 

The lipid bubbles are more correctly called nanostructured lipid carriers (rather like liposomes), or NLCs.

Researchers set out to develop a system that reduced side-effects and chemo-resistance that builds up over time.

Dr. Nasser Samadi led the study which is recorded in the journal ‘Colloids and Biointerfaces‘.

This is not the first time that melatonin has been shown to help Tamoxifen work. We also covered research in Cancer Watch that ElectroMagnetic Fields (known to reduce production of melatonin in the body) could inhibit the action of Tamoxifen.

Melatonin has many health benefits

Melatonin is often incorrectly referred to as a ’sleeping drug’. It is predominantly made in the body by the pineal gland, although research shows certain gut bacteria also make it as part of their circadian rhythm. The primary function of melatonin is to put the body into a deeper sleep.

But melatonin is more than that - it is a powerful antioxidant and an anti-inflammatory compound, which is why deep sleep is so healing.

Next, it can balance and correct over-production of the hormones oestrogen and growth hormone in the body. Both of these are involved in driving many cancers. 

Finally, melatonin has been shown to possess epigenetic properties, meaning it can correct cells where there has been a build up of methylation causing blockages in the sending of messages. This occurs in chronic illness such as cancer and Alzheimer’s.

We have suggested previously that all adults over the age of 50, who have disturbed sleeping patterns or do not get sufficient sleep, look into taking melatonin supplements - the usual dose is 3 mgs. It can be bought on the Internet in the UK or from many stores in the USA.

Melatonin involved in oestrogen-dependent cancers

Various studies over the last 10 years have shown conclusively that women who have disturbed sleep patterns - like long haul air hostesses, night shift workers such as nurses, and even people who stay out late three times a week or more - all have a higher risk of breast cancer. Men too with prostate cancer.

Equally EMFs reduce melatonin production and have been linked to a higher risk of these oestrogen-driven cancers.

We routinely suggest that all people with oestrogen-driven cancers ensure they are getting enough quality sleep, or top up their melatonin levels. Melatonin is also known to change oestrogen receptor sites on cells, blocking dangerous oestrogens like oestradiol from binding there.

All this research and more is in Chris ‘ book ‘Everything you need to know to help you beat cancer’.

2016 Research
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