A number of new research studies have shown that infection, particularly with flike, plays a significant role in cholangiocarcinoma (bile duct cancer) causing most, if not all cases of this disease.
Bile Duct cancer, also be called Biliary Duct cancer, or cholangiosarcoma is infact a cancer of the biliary duct system, which includes the gallbladder, certain cells inside the liver and the bile ducts. This cancer is on the increase in the Western world.
Many internal organ cancers (for example, kidney cancer and bladder cancer) are linked to higher levels of yeasts and Escherichia coli. Dealing with them has been known to help rid the patient of their cancer. But this is often also ‘background noise’, and something more sinister may well be in play.
Dysbiosis in the Bile Duct Microbiome
We know that the bile duct has its own microbiome and the membership reflects the gut microbiome membership. A Japanese metagenomic study (1) analysed the microbiota in bile and faeces and found that patients with bile duct cancer had high levels of cancer-causing Enterobacteriaceae and lowered levels of Clostridia. Worryingly, this shortfall included butyrate-producing bacteria such as Faecalibacterium and Coprococcus. Worse, metagenomic analysis revealed that the strains isolated from the bile included bacterial genes capable of producing carcinogenic Coli Polyketide synthases (or PKS).
Butyrate is a very important short chain fatty acid having many functions, not least it is important for intestinal health. It is anti-inflammatory and can heal the gut wall. It also activates vitamin D turning it into the form that can activate your immune system. It also helps colonise commensal bacteria in the microbiome. And importantly, it can attack developing cancer cells. Lower levels of butyrate and/or the microbes which produce it, are associated with disease and poorer health outcomes. Dysbiosis (an imbalance of the gut microbiome) causes disease and illness.
Butyrate is made by friendly bacteria from foods high in soluble fibre - oats, pulses, vegetables and nuts and seeds. Pectins are good foods for all three short chain fatty acids (and so are butter, cheese and milk products but beware the saturated fat and cholesterol produced. You are dependent upon the presence of butyrate producing bacteria, and these are usually lost in Bile Duct Cancer (2).
Yeasts alone can lead to obstructive jaundice if not tackled. Biliary candidiasis has been found in patients with obstructive jaundice and regional malignancy (3).
We also know that the microbiome in the bile changes depending on a number of factors. For example, whether you have drainage or not, and on the exact location of the tumour.
Infection and Bile Duct Cancer
In extrahepatic cholangiocarcinoma, E coli presence can be a factor. We can kill it with lycopene, oregano oil and/or artemisinin. Other bacteria were found (4) at high levels, particularly, Enterococcus faecalis (38.8%), Enterococcus faecium (32.5%), Enterobacter cloacae (16.3%), and Escherichia coli (11.3%).
Liver Fluke
There's a link between bile duct cancer and liver fluke. In the UK, common liver fluke or sheep fluke is Fasciola hepatica, which you can pick up from eating undercooked meat or even watercress in the UK.These are less of an issue although Bioresonance studies are finding Fasciola more and more common and even in women with breast or ovarian cancer.
If abroad different species of fluke can be picked up from poorly cooked river fish and prawns.
Liver fluke are tiny parasitic worms, and those linked to bile duct cancer are more often found in the fresh waters of Southeast Asia. People can become infected by eating raw or under-cooked fish that are infected with these parasites. Once eaten, the liver flukes grow to adulthood inside the human biliary duct system; they can lay up to 500 eggs per day. The irritation and poisons of live fluke and/or the scarring caused by past liver fluke infection can lead to bile duct cancer.
Two types of fluke are commonly involved. One is Opisthorchis verrini, which is found in Thailand, Laos, Cambodia and Vietnam. The second is Clonorchis sinensis, which is present in rural areas of Korea and China. In the USA, the Centers for Disease Control and Prevention (CDC) have more information (5).
I have had a lady in India as a patient. When I suggested her Bile Duct cancer may have been caused by a parasite, she told me that everyone in the town had a parasite - from eating the fish. I have also had a number of women in the UK who visited North East Thailand, Laos, and/or Cambodia for holidays, and now had Bile Duct cancer. When they mention to their oncologist that the might have liver fluke, the reply is always, ‘Don’t you think I would have seen it?’ The answer is probably no. They are not in the liver, they are inside the duct.
You are very unlikely to be sick when contracting the fluke; it can be 20 years or more before it gives you any problems.
The US Veterans Association Public Health Dept cover liver fluke as a cause of BDC (6) because many of their members saw service in Southeast Asia during the Vietnam war.
Thailand, where I live several hours south of Bangkok, has the highest incidence of Bile Duct cancer in the World. Bile Duct and Liver cancer are the top two cancers in Thailand. As long ago as 2008, there was a review (7) of the areas in Thailand, from the North East (Isaan) to the North (Chang Rai) with a link between Opisthorchis viverrini and cholangiocarcinoma. Indeed the Hospital three hours North East of Bangkok in Khon Kaen, deals with more Bile Duct cancer patients than anywhere else in the world. The Mekong river yields a common dish (Koi Pla) of raw fish, herbs and spices like chilli, and even red ants are added. Tourist guides do talk about ‘cancer causing fish (8).
If fluke are in your bile ducts, you are more likely to get higher blood fat and even gallbladder issues and liver issues. And you can have lung flukes too!
Eradicating Liver Fluke
Fluke eggs can be killed by cloves. Fluke can be killed, we have a review on drugs and other compounds, but less and less so. And different fluke need different drugs.
The problem is that the drugs are losing effectiveness; nutritionists over claim what they can do, and we could give you Mebendazole, Fenbendazole and/or Ivermectin but they don’t always work. Para Free Plus also contains cloves which destroy the eggs. Neem, Turmeric, Apple Cider Vinegar and garlic seem useful.
Perhaps the best solution is to find a Bioresonance expert with a diagnostic machine that can also kill pathogens. Just ask them, “What exactly is infecting me?”
Is Bile Duct Cancer always a case of Liver Fluke infection?
Singapore researchers have studied BDC - both fluke-linked and non-fluke linked (9).
Where fluke ARE present, so too are Enteric bacteria (as found in research above) and these produce cancer-causing metabolites. Where fluke were NOT involved bacteria from the Stenotrophomonas species were found in BDC. It's gram negative and linked to cancer. We always aim to kill these too.
Go to: What people say about a Personal Prescription with Chris Woollams
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References
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Dysbiosis of the Fecal and Biliary Microbiota in Biliary Tract Cancer; Zensho Ito et al; MDPI, Cancers; Volume 14; Issue 21;
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Butyrate’s role in human health and the current progress towards its clinical application to treat gastrointestinal disease; Kendra Hodgkinson et al; Clinical Nutrition, Volume 42, Issue 2; February 2023, Pages 61-75
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Intractable Biliary Candidiasis in Patients with Obstructive Jaundice and Regional Malignancy: A Retrospective Case Series;’ Abdel rahman A Al manasra et al; Clin Exp Gastroenterol. 2021; 14: 83–89
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Interplay between the Human Microbiome and Biliary Tract Cancer: Implications for Pathogenesis and Therapy; Cheng Ye et al; Microorganisms. 2023 Oct; 11(10): 2598
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CDC, About Liver Flukes - https://www.cdc.gov/liver-flukes/about/index.html?CDC_AAref_Val=https://www.cdc.gov/parasites/liver_flukes/index.html
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US Dept of Veterans Affairs - https://www.publichealth.va.gov/exposures/infectious-diseases/cholangiocarcinoma.asp.
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Cholangiocarcinoma: lessons from Thailand; Banchob Sripa, Chawalit Pairojkul; Curr Opin Gastroenterol, 2008 May;24(3):349-56.
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What You Need to Know About Thailand’s Cancer-Causing Fish - https://theculturetrip.com/asia/thailand/articles/what-you-need-to-know-about-thailands-cancer-causing-fish
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Scientists discover unsuspected bacterial link to bile duct cancer; ScienceDaily, 24 June 2016.
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