A single strain of gut bacteria, Lactobacillus johnsonii, taken orally is capable of reducing risk of Lymphoma in genetically predisposed high-risk people.
Ataxia-telangiectasia is a genetic disorder associated with high incidence of B-cell lymphoma in humans. But that alone is not enough to cause either Hodgkin’s Lymphoma or Non-Hodgkin’s Lymphoma. Diet, lifestyle and Environmental factors each have an impact on the gut microbiome and it seems the make-up of the 90 trillion bacteria in your gut can develop or prevent the condition.
Using mice, which exhibit the same traits as humans for A-T and lymphoma, the researchers from Jonsson Comprehensive Cancer Center (JCCC) at the University of California in LA (UCLA), conducted high-throughput sequence analysis of rRNA genes to identify the gut microbiome make up.
Not only did they find that Lactobacillus johnsonii was deficient in the more cancer-prone mice but that, by reintroducing the bacterium orally, they could reduce the genotoxicity, reduce basal leukocytes and the cytokine-mediated inflammatory state, and deliver a lowered rate of lymphoma.
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Reference:
- Mitsuko L. Yamamoto, Irene Maier, Angeline Tilly Dang et al; Cancer Research; DOI: 10.1158/0008-5472.CAN- 13-0022 Published July 2013)