A mushroom ingredient to treat HPV infection?

A mushroom ingredient to treat HPV infection?


An active hexose compound found uniquely in Shiitake mushrooms and called AHCC, uniquely eradicates at least half of all HPV cases when used for 6 months, according to a Phase I clinical Trial.

The latest study (1) by Dr. Judith Smith, associate Professor at MD Anderson, McGovern Medical School in Houston, Texas showed that “AHCC 3 g once daily was effective to support the host immune system to eliminate persistent HPV infections and was well tolerated with no significant adverse side effects reported”.

This follows work (2) from 2014 where this, alpha-glucan polysaccharide found in Shiitake mushrooms, eradicated HPV in three separate studies, two in vitro and one with mice.

The new 2022 study was a randomised, double-blind, placebo-controlled study in 50 women over 30 years of age followed for 12 months. All patients had confirmed and persistent high-risk HPV infections for longer than two years.

In this trial, the AHCC was provided as a supplement of lentinula edodes mycelia or LEM. This was provided by Amino Up, Ltd., Sapporo, Japan. The extract, AHCC, is a proven immune system booster; for example, a 2017 trial with breast cancer showed that women taking anthracycline drugs (for example, cyclophosphamide, epirubicin, 5-FU) received significant T-cell enhancement and a better quality of life (3).

Of the 50 women divided into 2 randomised groups, 63.6% of the patients in the AHCC supplementation arm were HPV negative after 6 months, with 64.3% of those achieving a durable response (HPV negative after a further 6 months without supplementation).

Chris Woollams, former Oxford University Biochemist and a Founder of CANCERactive added, “This research is very promising. Clearly,  AHCC is a good immune booster from a number of studies, as are many polysaccharides from mushrooms; and we know that the immune system can knock out HPV in the body. However we also know that, like Herpes 8, HPV can lie dormant in the nerves, coming out to play when the immune system is weak. 6 months of AHCC saw a result in the blood tests for circulating HPV. Longer studies are needed now to find out if it is leaving the nervous system as well, or if people infected with HPV need to take it for a much longer time period to be completely rid of the virus.

In the past we have seen Pau d’arco, artemisinin, turmeric, ellagic acid (from raspberries) and graviola each have an effect at various stages of HPV infection. HPV infection and advanced cervical cancer is on the increase (4). HPV infection is also found in 10-15% of throat cancer (Head and Neck Cancer), where it seems more likely to metastasise (5) according to new research from Dana Farber Cancer Institute.”.

Go to:  Latest News, Cervical Cancer



  1. AHCC® Supplementation to Support Immune Function to Clear Persistent Human Papillomavirus Infections; Judith A Smith, Anjali A GaikwadL Lata Mathew , Barbara Rech , Jonathan P Faro , Joseph A Lucci 3rd , Yu Bai, Randall J Olsen, Teresa T Byrd; Frontiers in oncology; 2022 Jun 22;12:881902. doi: 10.3389/fonc.2022.881902

  2. Mushroom eradicates HPV from the body - https://chriswoollamshealthwatch.com/your-illness/general-health/mushroom-eradicates-hpv-from-the-body/ 

  3. Lentinula edodes mycelia extract plus adjuvant chemotherapy for breast cancer patients: Results of a randomized study on host quality of life and immune function improvement; Yukiko Nagashima, Shigehumi YoshinoMol et al, Clin Oncol, 2017 Sep;7(3):359-366.

  4. Advanced stage cervical cancer on the increase in USA - ABC news, August 23rd 2022

  5. Study findings in metastatic HPV-linked head and neck cancer may help guide treatment, Dana Farber Cancer Institute


  Approved by the Medical Board.  Click Here



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