Two studies show importance of Vitamin D with triple negative breast cancer

2013 Research
Two studies show the importance of vitamin D with Triple Negative Breast Cancer.

Researchers led by Susana Gonzalo, Ph.D., assistant professor of biochemistry and molecular biology at Saint Louis University studying the BRCA1 gene mutation, have identified the pathway involved. This frequently leads to Triple Negative Breast Cancer (TNBC) an aggressive form of the disease. When the pathway is active, tumours grow rapidly. However the researchers showed that vitamin D could block the pathway.


This could be extremely important as currently chemotherapy options for TNBC are poor and younger women tend to develop the disease.


Clinical trials are now planned.


Importantly, a second completely unrelated study seems to back up these findings. According to a study in the Journal of Cellular Biology, researchers found that a protein (53 BPI) normally inhibits cancer cell growth but a compound call cathepsin L can invade the cell’s nucleus and block 53 BPI causing uncontrolled cell division and cancer cell growth. Apparently vitamin D blocks cathapsin L. Again, the researchers were studying TNBC.


Vitamin D has previously been shown in research in Cancer Watch, both to prevent AND correct cancer. It is not really a vitamin, but actually works like a hormone and has proven epigenetic benefits - it can reverse genetic blockages cause by methyl bonds erroneously formed due to damage through a poor diet, environmental toxins, stress or hormones such as oestrogen.  Indeed vitamin D (along with curcumin) has been described as the ultimate epigenetic.

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2013 Research
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