Ten natural compounds that have been shown to fight, reduce and prevent chemoresistance, and extend the life and effectiveness of your drugs.
Chemoresistance is a real problem; it is why cancer drugs stop working after a while. It builds up over time in cancer cells making the drugs weaker and weaker. This can be worrying for all patients, especially those taking a drug that has resulted in stable disease.
We do know reasons why this can happen. For example, Galectin-3, or Gal-3, is a current target for scientists looking for new anti-cancer drugs. It builds up in cancer cells helping metastasis and promoting chemoresistance - for example in Breast cancer (1). Modified Citrus Pectin is known to block Galectin-3 (2).
How might cancer cells be ‘sensitised’, so that the chemo works better and longer? Plants seem able to help (3).
In no particular order, here are ten natural compounds that are known to reduce chemo-resistance. We will amplify this Blog over coming weeks. We prepared it to urgently help a couple of patients.
Ten natural compounds to reduce chemo-resistance and extend the life of drugs
1. Berberine
2. Quercetin
3 Honokiol (TCM from the magnolia bush)
4. Melatonin
5. Turmeric
6. Modified Citrus Pectin
7. Resveratrol
8. Milk Thistle
9. Turkey Tail Mushroom Extract
10. Ursolic Acid (holy basil, pistachio nuts)
In most cases the research to date only covers a natural compound with one or two drugs and a specific cancer. But I will amplify this list with more evidence as I get time.
For the record, Hyperbaric Oxygen increases chemosensitivity and reduces chemoresistance; and two off label drugs can extend the life and effectiveness of drugs - Ivermectin and Niclosamide.
All the above compounds are covered on this website.
Go to: Natural Compounds that can help PARP drugs work better.
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References
1. The expression of galectin-3 in breast cancer and its association with chemoresistance: a systematic review of the literature; Ioannis Boutas et al; Arch Gynecol Obstet, 2019 Nov;300(5):1113-1120.
2. pH-Interfering Agents as Chemosensitizers in Cancer Therapy; Liora Colobatiu, Laura Gavrilas, Andrei Mocan; Science Direct
3. PectasolC Modified Citrus Pectin targets Galectin3induced STAT3 activation and synergize paclitaxel cytotoxic effect on ovarian cancer spheroids; Ghamartaj Hossein et al; Cancer Med. 2019 Aug; 8(9): 4315–4329.