Novel cancer treatment targets cancer cell Achilles Heel

Novel cancer treatment targets cancer cell Achilles Heel

Cancer cells burn common glucose (or High Fructose Corn Syrup) in the absence of oxygen. It is called glycolysis. The waste produced is Lactic acid, a highly toxic substance. This is rapidly removed from the cell, and ultimately denatured by the liver.

But, what if you could stop the Lactic acid leaving the cancer cell? Dr. Young Hee Ko a Biochemist was working with Peter Pederson at Johns Hopkins on sugar and cancer and now works on cancer metabolism at KODiscovery in Maryland University’s Biopark.

Cancer cells produce a transfer system to help the Lactic acid drainage.  This involves monocarboxylic acid transfer prosphates. Ko has been using a chemical called 3-bromopyruvate (3BP), which blocks the transfer. Result, in over 100 studies, the Lactic acid cannot escape and the cancer cells poison themselves. End! The cancer tumours self-destruct.

2016 Research
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