CBD capable of blocking metastasis in aggressive cancer

CBD capable of blocking metastasis in aggressive cancer

CBD can slow down and even halt the progression of breast cancer, even in its later stages, by switching off a protein Id-1 which causes that final and fatal step, according to research from the California Pacific Medical Center and funded by the National Institutes of Health in the USA.

CANCERactive has previously covered research showing that the protein Id-1 is an inhibitor of transcription factors and a key regulator of breast cancer metastases. Id-1, or ID-1, stands for Inhibitor of Differentiation/DNA binding.

Indeed, Id proteins are over-expressed in many cancers; for example, in pancreatic, prostate, neuroblastoma and non-small cell lung cancer (NSCLC). It is known to have a number of roles (1) but targeting Id-1 results in decreased tumour growth and can even reverse aggressive cancer.

In a previous study, researchers had shown that human metastatic breast cancer cells became less invasive in vitro and less metastatic in vivo mice when antisense Id-1 was used (2).

But antisense Id-1 cannot be used in humans. In this study (3), researchers used CBD oil. Unlike antisense it is non-toxic to healthy cells and can be used in situations where the immune system is low.

The researchers had previously shown that CBD could inhibit breast cancer metastases in mice; In this research, which researchers described as a ‘breakthrough’, they found that CBD inhibited Id-1 and metastases in human breast cancer.

The researchers stated that invasion and metastases is the final and fatal step in cancer. And here they had shown that Id-1 played a crucial role in that step. Now they have shown it could be inhibited successfully by CBD.

Chris Woollams, former Oxford University Biochemist said, “A lot of noise is made about Cannabis, but yet again CBD rather than the psychotropic THC is being shown to be effective, just as it was in research we covered on tumour regression in ovarian cancer recently. CBD or Hemp oli is totally legal today in the UK.”

Go to: The Difference between Cannabis and Hemp

Reference

  1. https://www.sciencedirect.com/science/article/pii/S0301468109602358
  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC263850/
  3. https://mct.aacrjournals.org/content/6/11/2921
2019 Research
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