An assessment of the NORI protocol

An assessment of the NORI protocol
The NORI Protocol
The NORI protocol or the Nutritional Oncology Research Institute protocol is an inexpensive and simple diet protocol to treat cancer and is based on the logic that cancer needs methionine to grow - so starve it of methionine! And the best way to achieve methionine deprivation is to focus on fruit.
The NORI Protocol - Methionine-deprivation and cancer restriction
1. The need for methionine
It is worth saying right up front that there is a fundamental problem in this theory - normal, healthy cells need methionine. It is an essential amino acid (that is, humans cannot make it) and, along with cysteine, it is a sulphur-containing amino acid. It is known to stimulate cartilage formation, it is important in the generation of new blood vessels, in liver health, and it helps in the formation of other sulphur-containing amino acids, peptides, proteins and RNA. A lack of methionine, especially in seniors, can result in muscle loss and methionine protects from fatty liver and liver degeneration. The
University of Pittsburg Medical School has shown that people vary in their needs but usually the daily requirement is 800 to 1000 mg.

However, you can consume too much, in which case research (2007, Journal of Biochemistry) has shown that the result is actually a loss of muscle mass, weight and protein. Excess methionine can be converted into homocysteine and there is an indication of an increased risk of Alzheimers.
Methionine can be recycled through homocysteine in the body. The build up of homocysteine is associated with increased risk of diseases such as cancer and Alzheimers. It is linked to methylation, histone build up and epigenetic blockage of DNA sequences. However, homocysteine cannot replace methionine. A 1974 paper showed that while healthy cells could use homocysteine, without methionine cancer cells die (https://www.ncbi.nlm.nih.gov/pubmed/4524624). 

Methionine is also involved in the production of polyamines, involved in cell division and found in high levels in tumour cells.

Go To: The Rainbow Diet and how it can help you beat cancer
2. Methionine-deprivation
Methionine and cancer is a well-researched subject. Methionine is essential to cancer cells. For example, a 2015 study by
Lamb et al shows its importance in forming Tumour Initiating Cells (TICs). And in vitro studies show methionine restriction leads to cancer cell death. The withdrawal of methionine thus aims to starve cancers in much the same way as calorie restriction does. Like calorie restriction, methionine restriction increases longevity in animals; and it improves insulin sensitivity.
Methionine-rich foods - beef, lamb, pork, chicken, turkey, prawns, fish, eggs, dairy, soy, nuts, grains and even seaweed.
Methionine-depleted foods are basically typified by a vegan diet - fruit is low with legumes actually lowest. However, the NORI protocol argues for fruits saying that green vegetables are higher in protein. This is not borne out on websites like Wikipedia.
Other elements used in the NORI Protocol - high dose selenium
Selenium has a number of effects. It is a detoxifier (or rather a displacer) of heavy metals. The NORI protocol uses Sodium Selenite - the NORI people say that this is the most active form and kills the most cancer cells at low levels. However, Dr. Mercola says that sodium selenite and sodium selenate are
dangerous to the environment and highly toxic being carcinogenic and genotoxic. In one study, sodium selenite was shown to induce substantial DNA damage.
In conditions where a body has low selenium, the maximum dose should be no more than 200 micrograms.
Genepin and vitamin E succinate in the NORI protocol
These are used because they are believed to cause apoptosis (cancer cell death).
The NORI PROTOCOL - a high fruit diet
So, the bottom line is the NORI protocol focuses on starving the body of methionine by feeding the patient a substantially fruit-only diet. The theory runs that a high fruit diet also contains enzymes that attack cancer cells; and a high fruit diet does not fill your body with sugar - quote
The natural sugars will not feed cancer or cause tumours to grow.
The methionine restriction sensitises the cancer cells and the methionine and genepin/sodium selenite finishes them off.
The diet has to be broken every now and then to allow the healthy cells to recover.
The NORI DIET - the CANCERactive view
Chris Woollams founder of CANCERactive and former Oxford University biochemist summarised by saying,
"There were just a few too many claims on their website, with too few scientific references. I can see the whole logic and theory about methionine. That is clear and there are quality research studies. But then most analyses show vegetables are lower in methionine than fruits. And some of the other elements rely too much, in my opinion, on views not research.
Id also like to see a few real-life epidemiology studies or a study where people who adhered closest to the diet survived longer. There was no research in connection with the protocol, for example, that showed people who adhered most closely to the diet developed less cancer, or were more likely to be cancer-free, as there is with the Rainbow Diet. Unfortunately the whole world of cancer falls down all too frequently between theory and practice.
I also think the science behind methionine-deprivation is interesting and just as supporting of the Rainbow Diet and the idea of Eat a Rainbow. I see no reason to modify the CANCERactive view that the Rainbow Diet is the best anti-cancer diet available to people who want to protect or correct. More information and research can be obtained on The Rainbow Diet and cancer, diabetes, heart disease, strokes, Alzheimers etc. via the links below".

Go To: The Rainbow Diet - and how it can help you beat cancer
Go To: The Rainbow Diet significantly reduces the risks of cancer

Go to: Eat a Rainbow - prevent and correct chronic diseases


An assessment of the NORI protocol
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