A high PSA may be due to the drugs you take, not your prostate

A high PSA may be due to the drugs you take, not your prostate

Blood thinners and PSA


Pradaxa (Dabigatran etexilate) is an oral medication which claims to be ‘the only oral blood thinner with a specific reversal treatment to lower your risk of stroke’. It is FDA approved and is one of the new breed of blood thinners (as opposed to Warfarin) used in over 3000 hospitals in the USA.


In two male patients at CANCERactive recently, it also greatly raised their PSA levels to the point both they and their doctors were convinced they had prostate cancer. In one male aged 63, coming off the drug caused his PSA to fall from 12.5 to 7.8 in less than 2 weeks. In the other it fell from 7.8 to 3.8. This is significant in that the 3.8 figure brings the patient back inside the ’acceptable range’.


Dabigatran is an anticoagulant and is not recorded officially as affecting PSA levels. However, you can find concerns on the Web. According to the manufacturer’s website, it can cause bleeding, internal bleeding, swelling, joint pain, indigestion, stomach upset or burning.


Steroids and PSA


Manufacturers argue that many older males have various illnesses such as high blood pressure, high LDL and a greater risk of cardiovascular disease, so is that the real problem, or is it the drug? Chicken or egg? But there have been studies(1) where common drugs were used in vitro on prostate cells, and shown to cause a PSA increase. Steroids dexamethasone and betamethasone were examples. 


Statins and PSA


On the other hand, statins are known to produce lower readings. In one study(2) statin use reduced prostate size on average by 8% and PSA by 12%. And it varies by statin. Simvastatin was shown to reduce prostate size, while atorvastatin reduced PSA levels.




A third study(3) showed non-aspirin NSAIDs reduced PSA levels, with aspirin and paracetamol less so.


Is natural better?


Lycopene, a bioactive compound found in tomatoes, is known to reduce blood pressure and LDL levels. Harvard Medical School produced research showing it also lowers PSA levels. Research shows a 25mg supplement daily reduces LDL by 10%, and the reduction is dose dependent. Curcumin added with the lycopene will enhance this. Maybe you just don’t need a statin?
Go to: Is lycopene better than statins?


Furthermore, high lycopene intake is linked inversely to total prostate cancer,  PSA and, more strongly, with lethal prostate cancer according to a 2014 study from Harvard. It stopped the formation of new prostate cancer blood vessels (4).


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1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3997723/
2. Cancer Causes Control. 2011 Mar;22(3):417-26. doi: 10.1007/s10552-010-9713-4. Epub 2010 Dec 19.
3. Int J Cancer. 2011 Mar 15;128(6):1442-8. doi: 10.1002/ijc.25465
4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3952200/




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