Salvestrols cause cancer cell death

Salvestrols cause cancer cell death

Salvestrols are natural 'pro-drugs - compounds found in plants and fruits, which on contact with the CYP1B1 enzyme unique to cancer cells, convert into poisonous compounds that kill the cell; they were discovered by Professor Gerry Potter, who also helped create prostate cancer drug, Abiraterone. 

Foods that can protect and correct

Back in 2005, Chris Woollams, former Oxford University Biochemist and a founder of CANCERactive wrote a book, The Rainbow Diet - and how it can help you beat cancer’ - in it he argued that the colourful Mediterranean Diet contained many bioactive compounds, such as flavonoids and polyphenols, which could potentially protect and correct humans in the fight against cancer.

There are may important compounds in fish oils, olive oil, nuts and seeds, and in the red grape skins (resveratrol) and pips (grape seed extract), in aubergines and cherries (anthocyanins) and kale, broccoli, cabbage, herbs and other foods. All these are eaten fresh and in season.

As a little example, Professor Robert Thomas wrote an article for CANCERactive on how polyphenols are hugely powerful in managing prostate cancer - he created POMI-T; its use reduces PSA levels by 67%. Then in 2012, the National Cancer Institute in America produced research showing that while consuming bad foods could encourage a cancer to regrow, consuming healthy foods containing certain bioactive natural compounds like suforaphanes and EGCG could stop that regrowth.  

Of course nature would have foods and ingredients that protect us! We wouldn't be here today if it didn't.

Your body has a 'nutritional rescue mechanism'

In 2002, Gerry Potter, Professor of Medicinal Chemistry at DeMonfort University's Leicester School of Pharmacy hypothesised that it was likely that there were natural compounds in foods that could block cancer cells' metabolism and lead to cancer cell death, or apoptosis.

He then identified and detailed a nutritional rescue mechanism that linked specific compounds in some of the most common foods we eat, with cancer cell death. This rescue mechanism hinged on a particular cytochrome P450 enzyme, CYP1B1.

There are cytochrome P450 enzymes (about 5,800 enzymes in total) existing throughout nature. 57 cytochrome P450 enzymes exist in humans. These enzymes have many functions; for example, they have the ability to make toxins and drugs water soluble and so clear them from the body. Some are our natural ’detox’ mechanism.

Importantly, one particular P450 enzyme CYP1B1 is uniquely expressed by all cancers, regardless of oncogenic origin, while being absent from healthy cells (Murray GI., et al; University of Aberdeen 1995). It has also been found throughout all stages of cancer - from precancer to late stage cancer -  and is widely regarded as a universal cancer marker.

CYP1B1 - the downside 

Not surprisingly given P450 enzymes are detox agents, CYP1B1 was found to detoxify chemotherapy drugs like Docetaxel, Tegafur, Flutamide and Tamoxifen (Macfadyen MCE et al 2004). This is how cancer cells resist chemo drugs - they detoxify them!
 
The enzyme can also take pro-carcinogens in tobacco smoke and turn them into full carcinogens (Port J et al 2004). And CYP1B1 can take weak forms of oestrogen and turn them into more aggressive forms. But, of course, this only takes place in cancer cells.  

But with people taking B-17, whether it be as amygdalin from apricot kernels or the concentrated, synthetic form laetrile, B-17 inhibits the CYP1B1 enzyme and prevents the salvestrols from working.  Thus you cannot mix B-17 and salvestrols.

CYP1B1 and Salvestrols

Professor Potter had already designed a pro-drug inhibitor (abiraterone acetate) for a cytochrome P450 enzyme in prostate cancer. cells. The drug Abiraterone is now a well-established treatment for prostate cancer.

So when a colleague, Dan Burke, Professor Emeritus of Pharmaceutical Metabolism, explained to him about the unique CYP1B1, Potter wondered if there were pro-drug inhibitors for that too.  CYP1B1 has, after all, been around in nature for thousand of years. 

First, like his work on Abiraterone, he designed a pro-drug that was benign but once it was in contact with cancer cells' CYP1B1 would turn into a highly toxic drug and kill the cancer cell. This he called Stilserene. As with Abiraterone and prostate cancer cells, laboratory testing showed Stilserene effective in 95 per cent of cases with breast cancer cells. Since healthy cells do not carry the CYP1B1 enzyme, this really was a seek and destroy, pro-drug. However, of course, this now needed to go through very lengthy clinical trials, and these could take years. Since Potter was convinced the theory worked, and given that the CYP1B1 enzyme has been around for thousands of years, he hypothesised that there were naturally many benign pro-drugs in nature that could similarly be turned by CYP1B1 to toxic killers, unique in cancer cells.

At the same time there was an explosion in research into a natural compound called resveratrol, a compound found in red grape skins.

Resveratrol had already been shown to have anti-cancer properties (for example, Jang M et al 1997, and 1999). It is a stilbene and stilbenes are polyphenols. Another stilbene is pterostilbene. These are found in a wide variety of foods but only in very small amounts. And Stilbenes are very close in formula to his original benign pro-drug Potter had created, Stilserene.

In summary: CYP1B1, which is unique to cancer cells, metabolizes a specific class of natural dietary compounds into anti-cancer toxins, and Professor Gerry Potter and Professor Dan Burke called these compounds Salvestrols.

What foods naturally contain salvestrols?

Salvestrols can 'correct and protect'. When a plant is attacked, salvestrols are produced primarily at the site of attack (the grape skin, or a plant root). They are natural anti-fungal agents and all cause the same P450 response in plant or in human situations.

Thus a seemingly random collection of unrelated foods produce natural compounds to ward off attacks by fungi or predators. The most notable is resveratrol but there are many others. Although these foods contain sugars which attract the predators, many products (the skins) containing the active ingredient tend to be bitter.

The list of salvestrol containing foods includes: 

Broccoli, cabbages, kale, savoy, Brussels sprouts, cauliflower, kohlrabi, Chinese leaf, spinach, chard, lettuces, watercress, green beans, broad beans, garden peas, artichokes (globe), red & yellow peppers, beansprouts, celery, salad rocket, avocado, pumpkins, squashes, gourds, marrows, zucchini, cucumbers, melons, gherkins.    

Also, all red fruits such as strawberries, raspberries, grapes:and plums plus blackcurrants, redcurrants, blackberries, blueberries, mulberries, cranberries, bilberries.
And apples, pears, pineapples.And herbs such as parsley, sage, rosemary, thyme, basil and mint. 

Do Salvestrols deliver?

In the Journal of Orthomolecular Medicine Vol 25, No. 1, 2010 (with authors Brian A. Schaefer, D.Phil.,Catherine Dooner, B.A, M. Danny Burke, Ph.D, Gerard A. Potter, Ph.D) there was a presentation of case histories involving five cancers, breast; prostate; colon; liver; and Hodgkins lymphoma. To quote the authors, Two of the cases show how rapid and dramatic the improvement can be when nutritional deficits are addressed. In each case of the five studies the patient used Salvestrols to significant effect

Salvestrols can help correct modern nutritional deficiencies

Salvestrols operate through a highly targeted mechanism that hinges on their metabolism by the universal cancer marker CYP1B1. Most usually this simply makes up for previous nutritional deficiencies.

Unfortunately, modern farming practices, for example spraying fruits with pesticides, reduces production of these natural defensive compounds. GMO foods will not need them, pasteurizing fruit juices decreases them, and modern diets simply do not include these common foods like cabbages and raspberries and so people lack these important phytonutrients.

These phytonutrients are all phytoalexins and are not induced in abundance until the plant comes under attack from infection or predation. If modern farming prevents the attack through spraying or GMO then the phytoalexins are simply not made.

Salvestrols operate in prevention and correction

Salvestrols operate as natural pro-drugs, uniquely targeted to killing diseased cancer cells while leaving the normal cells alone. Initial research indicates that this mechanism could operate both preventatively, killing off cells as they become cancerous, and therapeutically, killing off cells that are part of active disease.

The authors of the above paper conclude "within the context of a nutritional approach to treating cancer, this mechanism appears to significantly reduce cancer cells in the body and thus increases the chances of a beneficial outcome for a cancer sufferer".

It is also true that when one chooses to employ Salvestrols in combating disease, a broader nutritional approach will maximise the efficient operation of this rescue mechanism. Co-factors such as biotin, vitamin C, vitamin B3 (niacin), magnesium and iron are all known to be important and can improve effectiveness. Other nutritional components, such as fatty acids, probiotics and selenium, can also play important roles.

Does any research show resveratrol corrects cancer cells?

 Yes. Resveratrol has been shown to be attacked by PYC1B1 in pre-cancer and cancer cells to produce the toxic substance, piceatannol, which brings about cell death. The anti-cancer agent piceatonnal is only created by the cytochrome P450 enzyme CYP 1B1. (Br J Cancer, 2002; 86: 774-778).

Go to: More details on resveratrol

Founders accused by skeptics - Conflict of Interest?

There may well be none pro-cancer drugs and salvestrols could well be the ultimate agents of Prevention and Correction. But skeptics say despite all the research studies, it is important to point out that in some the leading researchers have developed the range of Salvestrol products that they sell.

Dr. Brian Schaefer is a Director of Acquired Intelligence Inc, the Canadian and US distributor of Salvestrols. Professor Dan Burke is a shareholder of Salvestrol Natural Products, the UK developer of the salvestrol technology. Professor Gerry Potter is a shareholder of Salvestrol Natural Products, the UK developer of the salvestrol technology.

Wouldn't you develop products if you'd done this work? Didn't the pharmaceutical companies sell Abiraterone after Potter developed it? 

Several salvestrol products are available:

Salvestrol Platinum for people with cancer; plus Salvestrol Gold for prevention, Salvestrol Professional, Salvestrol Shield plus a topical cream. Each has a points system to indicate strength and each is all natural.

Please note that salvestrol products do not contain naringenin, a compound commonly found in grapefruit, which may interact with several CYP enzymes and could therefore interfere with some drug therapies.Salvestrols can be taken alongside cancer drugs.

"If you are already using Salvestrols and/or resveratrol you might be interested in what is available in the Our Natural Selection shop, CLICK HERE."

                                     * * * * * * * * 
References

We are indebted to Brian Schaeferfor for additional contributions to this article (www.salvestrols.com)

* Potter GA: The role of CYP 1B1 as a tumour suppressor enzyme. Br J Cancer, 2002; 86 (Suppl 1), S12, 2002.
* Potter GA, Patterson LH, Wanogho E, et al: The cancer preventative agent resveratrol is converted to the anticancer agent piceatonnal by the cytochrome P450 enzyme CYP 1B1. Br J Cancer, 2002; 86: 774-778.
*  Potter GA, Burke DM: Salvestrols Natural Products with Tumour Selective Activity. J Ortho Med, 2006; 21, 1: 34-36.
*  Tan HL, Butler, PC, Burke, MD, et al: Salvestrols: A New Perspective in Nutritional Research. J Ortho Med, 2007; 22(1): 39-47.
 * Murray GI, Taylor MC, McFadyen MCE, et al: Tumor specific expression of cytochrome P450 CYP 1B1. Cancer Res, 1997; 57: 3026-3031.
*  McFadyen MCE, Melvin WT, Murray GI.: Cytochrome P450 CYP1B1 activity in renal cell carcinoma. Br J Cancer, 2004; 91: 966-971.
*  McFadyen MCE, Cruickshank ME, Miller ID, et al: Cytochrome P450 CYP1B1 over-expression in primary and metastatic ovarian cancer. Br J Cancer, 2001; 85:2426.
*  Dana-Farber Cancer Institute: Cytochrome P450 1B1 is a Universal Tumor Antigen Eliciting Cytotoxic T Cell Responses, 2007. http://www.danafarber.org/res/technology/available.asp?case_number=641&keywords=&category_id=3&category_name=Researc+Reagents
*  Potter GA: The role of CYP 1B1 as a tumour suppressor enzyme. Br J Cancer, 2002; 86 (Suppl 1), S12, 2002.
* Schaefer BA, Hoon LT, Burke DM, et al: Nutrition and Cancer: Salvestrol Case Studies. J Ortho Med, 2007; 22, 4: 177-182.
* Ware WR: Nutrition and the Prevention and Treatment of Cancer: Association of Cytochrome P450 CYP1B1 With the Role of Fruit and Fruit Extracts. Integrative Cancer Therapies, 2009; 8, 1: 22-28.
* Ware WR: P450 CYP1B1 mediated fluorescent tumor markers: A potentially useful approach for photodynamic therapy, diagnosis and establishing surgical margins. Medical Hypotheses, 2009; 72: 67-70.
*  Bostwick Laboratories Announces uPM3(TM) Test, First Genetic Test for Prostate Cancer. September 23, 2005. http://www.psa-rising.com/wiredbird/bostwicklabs92303.php
* Product Monograph. Zoladex 10.8 mg Goserelin/depot. Luteinizing Hormone Releasing Hormone Analog (LHRH Analog). February 24, 2009. http://www.astrazeneca.ca/documents/ProductPortfolio/ZOLADEX%20LA_PM_en.pdf
* BCCA Protocol Summary for Treatment of Hodgkins Disease with Doxorubicin, Bleomycin, Vinblastine, and Dacarbazine May 1, 2009. http://www.bccancer.bc.ca/NR/rdonlyres/30FDD508-96AC-4555-B682-294EA3635B06/34011/LYABVDProtocol_1May09.pdf

You can find out more on ’The Rainbow Diet - and how it can help you beat cancer’ by clicking HERE 

                          CANCERactive - the appliance of Science







 

Vitamins, minerals, natural compounds and supplements
CancerAcitve Logo
Subscribe (Free e-Newsletter)

Join Our
Newsletter

Join Our Newsletter Signup today for free and be the first to get notified on new updates.