Can cannabis and cannabinoids cure cancer?
(Chris Woollams. CANCERactive) Can cannabis cure cancer? It increasingly looks promising. We have reached a crucial moment in the path of cannabis (marijuana) as a cancer treatment or ´cure´. Over the next 12 months there will be a number of companies - some on the stock market - from Canada to Australia, legally producing medicinal cannabis. This will also add some stability to a market where currently prices and quality are completely random and the internet is a minefield waiting to trap the unsuspecting.
Clinical trials on cannabis start now
A growing number of people, including cancer experts and scientists, believe that cannabis (marijuana; hemp) could be an effective treatment for cancer; some even believe cannabis has the potential to cure cancer. Experts in Spain like Dr. Christina Sanchez are adamant that cannabis kills cancer cells, not just in a plastic dish, but in human bodies too. There are quality research studies on cancers from Brain to Breast and Lung to Liver. Not just cannabis on its own - with glioma for example, there is research using a combination of Temozolomide and cannabis showing it improves results significantly.
Up front, it is worth making one point crystal clear - there is an incredible amount of good quality research on the effects of the active ingredients of cannabis - the cannabinoids.
Few people realise that the human body even makes some of these.
Their purpose? To calm and protect you.
Meanwhile, officialdom is quite clear: In the UK, possession of cannabis (marijuana) is currently illegal and its medicinal use restricted. Changes and deregulations in various pockets of the Western World are about to happen.
Importantly, a whole raft of clinical trials are underway - for example in Colorado where scientists are studying two extracts of cannabis on children with glioma. Another in Israel by Hadassah is looking at 100% pure CBD extract to see if it can stop ´terminal´ cancer.
At the end of this article, you will find a link to the International Journal of Cancer Research and Treatment
which lists many research studies on cannabis, much of which is very recent.
Also at the end of the article, you will find a link to a You Tube Video featuring expert in cannabinoid research, Dr Christina Sanchez, a microbiologist from Compultense University in Madrid.
Cannabis and medicine
The fact is that cannabis has been used in medicine as a natural remedy for centuries. That is not enough for the modern medical world that demands hard evidence of effectiveness and chooses to belittle the benefits of cannabis for lack of support. However, what I found surprised me - over 250 research studies, at least 150 appearing on PubMed. The research on the potential of cannabis is there, if you can be bothered to make the effort to look for it.
Effective use for side-effects
The US Government ´National Cancer Institute´
web site states: The potential benefits of medicinal Cannabis for people living with cancer include antiemetic effects, appetite stimulation, pain relief, and improved sleep. Although few relevant surveys of practice patterns exist, it appears that physicians caring for cancer patients in the United States who recommend medicinal Cannabis predominantly do so for symptom management.
So that´s a start - it has official ´approval´ for use with side-effects.
Cannabinoids - THC, CBD and others
The active ´ingredients´ of cannabis are called cannabinoids and there are 21 of them, each with distinct properties: One, tetrahydrocannabinol and termed THC, is the primary psychoactive component; others like CBD, or cannabidiol, are known to have analgesic and anti-inflammatory effects.
It is also important to point out that humans make certain cannabinoids in their bodies and these act to relieve pain. It is being increasingly shown that certain of them may even correct situations of ill health arising in the body.
Just a little of the Research
Frankly, I found a huge amount of serious research reports with ease when conducting my review of cannabis. To say there is ´no scientific evidence to support potential benefits´, as some orthodox cancer experts would have us believe, is rubbish. Cannabinoids seem to have potential with a great many cancers. The International Journal of Cancer Research and Treatment
has a very up to date list of research studies - Click here.
They seem capable of working on their own and/or even enhancing the properties of certain drugs.
For example, research studies have suggested that phytocannabinoids and endocannabinoids may be useful in the prevention and treatment of colorectal cancer
(One of many studies would be: Curr Clin Pharmacol
5 (4): 281-7, 2010).
In another study (Natl Toxicol Program Tech Rep Ser
446 (): 1-317, 1996) using THC, liver cancers
and benign tumours in areas such as the breast
were noted to decrease in line with dosage. Another study in vitro
and in vivo
related to lung cancers
(Br J Pharmacol
148 (2): 123-35, 2006). In 2007 a Harvard study concluded that ´THC cuts tumour growth in common lung cancer in half, and significantly reduces the ability of the cancer to grow´.
The study was done in both laboratory, and mouse experiments, and researchers concluded that THC affected certain receptor sites that stimulate cancer cell growth.
Further studies, for example one reported in 2008 in Journal of Clinical Investigation,
showed that THC could possibly be used to treat brain cancer
as it induced glioma death in laboratory experiments. This supported a previous study by Complutense University
in Madrid and the University hospital of Tenerife
and published in the medical journal ´Cancer Research´
on August 15th 2004. In this study researchers showed that cannabinoids could stop the action of Vascular Endothelial Growth Factor (VEGF) which is needed by cancer tumours to promote blood vessel growth. The research looked at glioma brain cancer, but was extended to other cancers where blood vessel growth was essential.
Brain cancer has been studied using THC to enhance the effects of Temozolomide (TMZ), and in separate studies CBD has been shown to cause glioma cell death. Indeed, sub maximal doses of THC and CBD made Temozolomide more effective in both TMZ-sensitive and TMZ-insensitive cancers.
A great many of the studies claim that cannabinoids may cause antitumor effects by various mechanisms, including induction of cell death, inhibition of cell growth, and inhibition of tumour angiogenesis and metastasis (for example, Nat Rev Cancer 3 (10): 745-55, 2003; FASEB J 17 (3): 529-31, 2003.; Br J Pharmacol 144 (8): 1032-6, 2005) Importantly, there is much research comment that cannabinoids appear to kill tumour cells but do not affect surrounding healthy cells.
The cannabinoid CBD has no psycho-active properties but has been shown in research to relieve side effects from inflammation and anxiety, to nausea. It has been used in the treatment of schizophrenia. Research shows that this compound too has anti-inflammatory and anti-cancer properties.
For example, The California Pacific Medical Research Institute looked into the use of CBD with cancer concluding that it could well be a significant and natural treatment with effect in hard-to-treat cancers. In their various studies, the researchers showed that CBD acted by blocking a gene responsible for metastases - the Id-1 gene - which is responsible for the aggressive movement of cancer cells away from a tumour site. Work has been conducted with both brain tumours and breast tumours.
Since CBD has no psycho-active properties, the research team argued that it´s use would not violate common law.
It is worth pointing out here, that there is huge debate on whether CBD or THC is the better; or what combination they should be in, for what cancer. Dr. Julian Kenyon of the Dove Clinic, Winchester, UK believes that CBD is doing all the work and the answer is a 100% synthetic CBD.
One World Cannabis, an Israeli-based developer of cannabinoid therapies have tried various balances in different formulae to deliver a significant effect against multiple myeloma. Clinical Trials Phase II are just beginning.
To date, a problem is that whilst there have been over 150 peer reviewed research studies, not once has there been a serious double-blind and controlled clinical study of the type that orthodox modern medicine acknowledges. I suspect this will end very soon. The Western world, with Government health agenies and drug companies clearly joined at both the hip and wallet will eventually be surpassed by work in other countries, entrepreneurs and patient power. Even cost considerations may encourage the reconsideration of cannabis as a cancer ´drug´.
There are already Biotech companies looking into cannabis. For example: There is one in Denver called Cannabis Science Inc claiming that numerous patients are reporting that Cannabis Science extract treatments are killing cancer cells. They have a Colorado-licensed dispensary and are pursuing Clinical Trials with the FDA.
It is worth noting that a common finding in my research trawl on the pages of the more staid health bodies and charities was this: Research from New Zealand concludes that smoking cannabis is 20 times more dangerous to your health than smoking cigarettes. Indeed, many cancer charities, when you search for cannabis and cancer, actually dwell on this research over anything else even remotely suggesting benefit!
Cannabis oil, or hash oil, is a thick resinous oil extracted from cannabis or hemp. It is often the form in which the treatment is commonly undertaken by ´alternative practitioners´. It has a very high THC content (between 70 and 90 per cent). Originally solvents used were often inflammable but now recipes (which are common on the web) use solvents like extra virgin olive oil. (see the Cannabis Chef).
Some complementary and alternative therapists argue for the use of cannabis oil, especially in the treatment of skin cancers. It can however be taken orally, but it is still an illegal substance.
Dr Christina Sanchez
from Compultense University in Madrid, Spain is an expert on cannabis and cannabinoids. In this You Tube video, she explains that certain cannabinoids are made by the body as a defence mechanism - and the very same ones are found in cannabis. See https://www.youtube.com/watch?v=1miGzTwK28U
Rick Simpson is a colourful character who used Hemp Oil to beat his cancer and he has spent many years perfecting the treatment process See http://phoenixtears.ca). His protocol is now perfected. He does not supply hemp oil himself but beware because a number of companies seem to pass off product as if it were his. One we have received testimonials about is this: Drricksimpsonmedicals@outlook.com
. We cannot vouch for it, and you will have to check your legal position.
To say that ´there is no evidence that alternative therapies like cannabis will make an objective difference´
(as I heard one cancer ´expert´ say on TV) is both ignorant and misleading. This small review shows that there is research - indeed, a lot of it - all suggesting that cannabis could play a part in a programme to treat cancer. But it is true that there are no ´Clinical Trials´ of the type espoused by medical experts in the UK. But then, at last count, only 15 per cent of drugs commonly prescribed in the Western World were supported by such rigorous Clinical Trial evidence yet medical ´experts´ continue to recommend the other 85 per cent with gay abandon. Is this just a case of the kettle calling the pot, ´black´? (Sorry, I couldn´t resist it!)
Many alternative treatments are ignored because they cannot be patented, and thus could not generate profit for pharmaceutical companies. This may, or may not, be the case for marijuana; cannabis; or hemp. I have the feeling that it will not be long before Clinical Trials are conducted and cannabis joins a long list of treatments for cancer, not merely being simply useful in managing side-effects.
As regular readers will know, we believe that your cancer is as individual as you are; that cancers can be ´cured´ today, or at least held in remission permanently; that there is no single cure for cancer - not a vitamin, drug, whatever - and that the way to increase your personal odds of survival is by building a tailored Integrative Treatment Programme.
So here is the You Tube made by Sharon Kelly on what she did to beat her stage IV lung cancer! She has achieved a remarkable change in her condition, and has been in remission for a year. Fingers crossed. CLICK HERE to watch.
CANCERactive - leading the way in Integrative Oncology.
It's the future.