Drug packaged in exosomes far more efficient
Researchers from the University of North Carolina at Chapel Hill have developed a revolutionary idea that means less chemotherapy can deliver even better results than normal.
They took a drug called paclitaxel (Taxol) which has some serious side-effects that were causing concern amongst doctors in the USA and ‘packaged’ the drug in ‘immune bubbles’ or exosomes, developed from the patient’s own white blood cells.
The ‘package’ prevents the destruction of the drug by the immune system and so delivers far more of the payload to the tumour, thus delivering all the benefits at much lower doses, with far less side-effects.
50 times less drug swarms cancer cells
"That means we can use 50 times less of the drug and still get the same results," said Elena Batrakova, Ph.D., an associate professor in the UNC Eshelman School of Pharmacy. "That matters because we may eventually be able to treat patients with smaller and more accurate doses of powerful chemotherapy drugs resulting in more effective treatment with fewer and milder side effects."
"We don’t know exactly how they do it, but the exosomes swarm the cancer cells, completely bypassing any drug resistance they may have and delivering their payload," says Batrakova
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